Some B vitamins might help reduce the pain associated with peripheral neuropathy, according to a study from the University Hospital in Coimbra, Portugal. A supplement combination of uridine monophosphate (UMP), folic acid, and vitamin B12 was given daily for two months to 212 patients with peripheral neuropathy and neuropathic pain. Results showed that the intensity of pain decreased during the course of the study. The global score for pain assessed using the painDETECT questionnaire dropped from 17.5 points to 8.8 pints at the final examination. The need for nonsteroidal anti-inflammatory drugs decreased or was withdrawn in 77.4% of the patients. The researchers conclude that this supplement combination “…leads to statistically significant reductions not only in the total [pain level]but also in the intensity of pain, number of areas affected, and pain radiation,” making it possible to reduce medication.
Negrao L, Almeida P, Alcino S, et al: Effect of the combination of uridine neucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Management 2014;May 16:1-6.