Aphthous ulcers are the most common ulcers of the mouth, with up to 50% of the general population experiencing one at some point in their lives. Researchers at Central Taiwan University of Science and Technology investigated the analgesic effects of vitamin B12 on treating these lesions. This was a randomized, double-blind, placebo-controlled trial of 42 patients suffering from aphthous ulcers. Pain levels were assessed before and after treatment with a topical vitamin B12 ointment. Results showed that pain levels dropped only in the vitamin B12 group within two days of treatment. The researchers conclude that, “…the results of this research study provide evidence that vitamin B12 is an effective analgesic treatment for aphthous ulcers.”
Liu H, Chiu S: The effectiveness of vitamin B12 for relieving pain in aphthous ulcers. Pain Management Nursing 2015;16:182-187.