High blood levels of homocysteine are associated with an increased risk for cerebrovascular events. Researchers at the University of Bologna, Italy report there is a supplement that can cut this risk. High dose supplements of folic acid or supplements containing 400 micrograms of methyltetrahydrofolate, 3 milligrams vitamin B6, 5 micrograms vitamin B12, 2.4 milligrams of vitamin B2, 12.5 milligrams zinc, and 250 milligrams betaine were given to 104 patients with an average age of 62.8-years. The participants had high blood pressure, but did not have a history of cardiovascular or cerebrovascular disease. After two months, results showed that both supplement programs lowered homocysteine levels in comparison to baseline; however, the combination supplement was considerably more effective. No side effects were reported.
Mazza A, Cicero A, Ramazzina E, et al: Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk. Journal of Biological Regulations and Homeostatic Agents 2016; 30:921-927.