Supplements of lipoic acid, quercetin, or resveratrol were effective at helping reduce weight gain and reducing oxidative stress to the heart in a study from Jiangnan University in China. Mice were fed either 1) high-fat diets or 2) high-fat diets supplemented with lipoic acid, resveratrol, or quercetin. After 26 weeks, body weights, blood pressures, thyroid hormones, oxidative stress markers and enzyme levels associated with heart function were measured. Results showed that the high-fat diet adversely affected all levels associated with heart disease. However, the animals also supplemented with lipoic acid, quercetin, or resveratrol showed less weight gain, restored thyroid function, and reduced enzyme activity, oxidative stress, and blood pressures. The researchers conclude that these compounds might have therapeutic potential for preventing or treating heart disease.
Cheserek M, Wu G, Li L, et al: Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. Journal of Nutritional Biochemistry 2016;33:36-44.